Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
While 221 people fell off the billionaires list this year, 198 people joined the ranks. Twenty-nine from the 2015 list died, while another 29 rejoined the list after having fallen off.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
As consumers in developing countries continue to shift to meat-based diets, grains and oilseeds used as livestock feed are expected to see support.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
British statisticians’ unwillingness to correct known errors in the clothing price component of the RPI redistributes many billions every year from students, recent graduates, taxpayers and rail commuters to index-linked UK government bondholders, wealthy pensioners with RPI-linked pensions and rail companies.
It’s the time of the year for list making! This Youku video clip named the nine hottest lines on China’s web this year. The Yangtze Evening Post, an influential newspaper, is the original list compiler.
Trends and targets in antiviral phototherapy
Extreme heat blanketed Alaska and much of the western United States last year. Records were set across large areas of every inhabited continent. And the ocean surface was unusually warm virtually everywhere except near Antarctica, the scientists said, providing the energy that fueled damaging Pacific storms.
Major areas of work for 2017
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
He did several makeup tests to get the look that would so dramatically change Mr. Carell. “We were literally creating a new human being,” Mr. Corso said.
Novel biosensing methodologies for ultrasensitive detection of viruses
“This young Vermonter clearly has an interest in service and anyone putting ideas forward with the goal of making Vermont a better place is appreciated here,” Scott's spokeswoman, Rebecca Kelley, tells PEOPLE.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Are you heading to Rio for the Olympics? Will you leverage the Google Maps app on Android or iOS? I think you already have the answer.
朱迪·福斯特（Jodie Foster）过去也将洗手间作为最佳选择 –“它们和水龙头看起来交相辉映”–但她已经为因影片《沉默的羔羊》（The Accused and Silence of the Lambs）获得的两尊小金人找到了一个更好的归属：奖杯盒。
ACE2 as a potential therapeutic target for pandemic COVID-19
She argues, however, that the problems with lower liquidity of ETFs in Asia are a symptom of a fund distribution system that fails to incentivise ETF sales by intermediaries. “I don't think there is a quick fix, but you would see a pick-up if Asia moves to a fee-based model,” she says.
Agricultural raw materials, especially the so called soft commodities such as sugar, coffee and cotton, have been among the top performers this year.
Diagnostic technologies for COVID-19: a review
Employees of state-owned firms also expressed more satisfaction with their bonuses than those at private companies – and little wonder, as the average payout at the former was Rmb17,318, or about Rmb6,000 more than what their private-sector counterparts could expect.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Wallace wrote the book after saying "yes" to everything for a year, a commitment which both advanced his career and landed him in a cult meeting. What the movie didn't show, however, is the sheer number of Internet scams Wallace signed up for. Apparently, saying "yes" all the time has its downfalls in real life.
Ms Lewis urged people to contact family, neighbours or an animal shelter if they were no longer able to care for their pets.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Two against-the-clock tours of Los Angeles. Two celebrations of the sometimes prickly solidarity among women. Four tremendous performances, from Kitana Kiki Rodriguez, Mya Taylor, Julia Garner and the great Lily Tomlin. “Grandma” is the work of a studio veteran. “Tangerine” was shot on iPhones. Anyone prone to lamenting the death of movies needs to shut up and watch these.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Below are a number of statements that people often use to describe themselves.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
The company realised that "it was all a mistake and that he did it without thinking," a Google spokeswoman said last Wednesday.
Antiviral drug discovery: broad-spectrum drugs from nature
Influenza neuraminidase: A druggable target for natural products
"How many patients do Chinese doctors see a day? It can be more than 50," he told China Daily. "How can we have the time and energy to do research or publish papers?"
20. 对电影爱好者的最佳建议。8月学者韦勒·温斯顿·迪克森(Wheeler Winston Dixon)发出了警告：“如果你上亚马逊，看到什么精彩的黑白电影卖三美元，或者其他什么外国电影和鲜为人知的电影，赶快买下来，因为它就要绝版了，他们不会再出版它们了。”成千上万这种VHS格式的电影不会被做成DVD格式或蓝光格式，迪克森警告说。而下载的美丽新世界（又名电子销售）明年将是好年头。
2. paparazzo /[复] paparazzi / n . 专门追逐名人偷拍照片的摄影者(或记者)，狗仔队。
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The quality of its students makes LBS particularly valued. “Studying among so many talented people has instilled in me the belief that I can actually achieve something on my own,” comments one MBA graduate from the class of 2011.
Hugo Boss, Chevrolet and Kleenex dropped off the list, the report said.
The role of biosensors in the detection of emerging infectious diseases
5.ah, you look great in that dress. – Because it’s better than being slapped。
Quantitative determination of mechanical stability in the novel coronavirus spike protein
In fact, one ancient saying was, "ifyou have Kucha, only one percent of the states in the Western Frontiers remain unsubmissive."
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Scientists may be working hard at making organs that match the body's capabilities, but why stop there?
'In the next 12 to 24 months, unless any of these bottlenecks are solved, we could see WTI going down to $50 a barrel, to incentivize producers to slow down,' she said
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Bernard Baumohl 作为Economic Outlook Group的首席经济学家，表示他甚至更乐观的认为接下来的两年将会成为至少近十年以来形势最好的两年，他还称“有很多证据充分的表明了经济正在恢复的势头”。
vt. 为 .
Inhibition of SARS coronavirus helicase by bismuth complexes
They appeared in high spirits despite losing three-nil to Belgium on Saturday .
Russia and Nato have both called for a de-escalation of the Turkey-Netherlands row.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
当时，身为首席执行官的库克也承受着压力，因为苹果除了从iPhone攫取利润之外，缺乏清晰的产品开发方向。维权投资者嗅到了血腥，开始围攻这家公司，打头的是大卫?艾因霍恩(David Einhorn)，接着是卡尔?伊坎(Carl Icahn)，他们游说改变苹果的经营和财务管理方式。伊坎施压要求苹果筹集巨额债务，向股东返还1500亿美元，并敦促苹果发布包括电视机在内的更多产品。
The reality turned out to be tougher than he imagined. “I saw it as a two-year opportunity,” says Mr Ravenscroft. “The grinding reality is that it’s a slog.” Moreover, his mentor worked at Lehman Brothers, the bank that collapsed in 2008. “It wasn’t quite as long a mentoring relationship as I’d hoped,” he laughs.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
The fact is, Hon Lik is not the first person to invent the e-cigarette. Way back in 1963, Herbert Gilbert made the world's first device that could be used to inhale tobacco-flavored air. In Gilbert's original version, there was no form of combustion and it was free of nicotine. He later designed a prototype that used a battery to create heat. He also used different flavors of water to create steam. He presented his prototypes to different chemical, pharmaceutical, and tobacco companies, but they simply turned down his prototypes.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
《发生什么了，西蒙妮小姐?》(What Happened, Miss Simone?)，导演：利兹·加布斯(Liz Garbus)。
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
5. How to play poker
Actor in a Comedy Series: Jeffrey Tambor, “Transparent”
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
There was no indication of the identity of the kidnappers or their motive.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
The current El , a naturally recurring phenomenon that warms the Pacific Ocean, was probably only responsible for about 10 per cent of 2015’s record-breaking temperatures, he added.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
In a humiliating 111-77 loss to the Golden State Warriors at Oracle Arena, Bryant shot 1-of-14 from the field, including 1-of-7 from 3-point range, and scored four points. He also shot 1-of-14 in a loss last season to the San Antonio Spurs.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
It was also the "most liked" tweet of the year, with 4.59 million likes.
联系方式:Staci Donegan and Peter Westley, Celia Dunn Sotheby’s International Realty, (912) 247-2052 / (912) 660-5169; celiadunnsir.com
Consumer prices rose 2.3 per cent year-on-year, more than expectations of 1.8 per cent. That is the biggest rise since July 2014. They had risen 1.8 per cent in January.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Whatever happened to ‘Never complain; never explain' – the unofficial motto of the House of Windsor?
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
However, the economists polled expect slightly higher growth rates and substantially higher inflation over 2016.
Huawei, the Chinese technology group, has taken market share from both Apple and Samsung, according to BrandZ.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
The reason why Blake looks the same today as he did in high school is because he's only four years removed from his high school years. Just imagine how monstrous Blake will look with another year or two of NBA training under his belt.
Bernard Baumohl, chief global economist of the Economic Outlook Group, said he is even more optimistic. "The next two years could be the best two we have seen in at least a decade," he said. "There is clearly a lot of evidence the economy is gaining a lot of momentum."
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
It was Somerset Maugham who said the French Riviera is “a sunny place for shady people” – and looking around at all the 'models' in the hotel lobbies and the men in dark sunglasses who seemed to know them, I knew what he meant. Behind the festival's shiny facade, there is an unseemly side – and beneath the azure waters, a polluted mess. The French diver and environmentalist Laurent Lombard's video of the Cannes seabed strewn with waste and debris went viral before the festival began. We were assured there was no danger to swimmers, and the mayor had it cleaned up according to the Daily Mail – but the Med had certainly lost some of its sparkle.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
The unprecedented declines have raised worries that the reserves could quickly evaporate if capital outflows continue and the central bank continues to defend the exchange rate. Most analysts believe the central bank will be forced to curtail its intervention in order to prevent further depletion of its reserves.
But a quick look at the changing skyline betrays a frustrating reality: Those shiny new towers have failed to deliver the type of housing most New Yorkers can afford. “There is a disconnect between what we’re building and what we need to build,” said Jonathan J. Miller, the president of the appraisal firm Miller Samuel. “2015 is going to be more of that.”
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
50个最优秀的“无工作经验要求”项目的所有毕业生中，三分之一以上毕业于英国的商学院。英国的商学院还吸引了近一半的女学生以及近一半的国际学生。实际上，2014年一个英国“无工作经验要求”金融硕士项目招收的学生中，有94%来自海外。这些学生当中约有85%来自欧洲经济区(European Economic Area)以外，55%来自中国内地。
The Lost Tomb
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Belgium, for example, has less than a tenth of the population of Russia, its rival in the group stage, but is regarded as a far greater threat. And then there is Uruguay, which despite fewer than 4 million citizens -- barely a sixth of the population of greater S?o Paulo -- is one of the teams Brazil would least like to meet on its way to the final. How is this so?
Writing for a Variety Special: Patton Oswalt, “Patton Oswalt: Talking for Clapping”
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
This habit can seriously hurt you in a work setting. If you’re one of those folks who believes that you do your best work at the last minute and put off projects or assignments until the day (or hour) before they’re due, you may not be aware of the impact your habit is having on your co-workers.If your last-minute rush requires others to work quickly, you will likely anger them, and you’ll be the first one blamed when a project fails or isn’t completed on time.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
6.Put people first
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Gitanjali won a $25,000 prize for scooping the top award.
Traditionalists include George Clooney, whose awards – best picture for Argo and best supporting Actor for Syriana – are in his library at home, and Dustin Hoffman, whose two best actor awards – the first for Kramer vs. Kramer in 1980 and the second for Rain Man nine years later, are kept in his study.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
他们两个自称拥有着世界上最大的两个粉丝基础。但是周日晚上，在伦敦温布利SSE竞技场上举行的2017年欧洲音乐大奖中，Shawn Mendes夺得桂冠， Taylor Swift在她参选的五个奖项中纷纷落选。
Stock pickers encountered difficulty this year in part because of concentration at the top of the market. Just five stocks—Apple, Berkshire Hathaway, Johnson & Johnson, Microsoft, and Intel— accounted for 20% of the market’s gains. If you weren’t at least equally weighted toward them, you had virtually no shot at making up for missing their enormous, index-driving gains. A majority of the market’s stocks did not perform nearly as well. According to the Leuthold Group, only 30% of S&P 1500 stocks posted gains exceeding the index itself. You’d have to go back to 1999 to see anything like this.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
“My manifesto with Summly was to get our technology into as many users’ hands as possible,” Mr D’Aloisio said, pointing to Yahoo’s hundreds of millions of users. “With Yahoo’s reputation as a content portal, we have an opportunity to fundamentally change the way content is consumed.”
After a run with One Direction, Harry Styles could have gone anywhere he wanted.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
Length-scale dependence of protein hydration-shell density
在这两个新指标方面，英国商学院的表现都优于法国商学院。在职业发展方面表现最好的英国商学院——华威商学院(Warwick Business School)在这一指标的总体排名中位居第二，高于法国在这方面表现最好的巴黎高等商学院(HEC Paris) 30个名次。在毕业后首份工作薪资与当下薪资比较方面，英国商学院校友的薪资增幅更大，为62%，法国商学院校友的薪资增幅为45%。然而，英国商学院校友的平均薪资仍低于与法国商学院校友，分别为5.5万美元和6.4万美元。
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Traditionally Chinese universities scored less well in international ranking tables compared to US and European incumbents in levels of teaching and research.
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China's box office sales hit a record high in 2015, by pulling in 44 billion yuan, or some 6.8 billion US dollars, with domestic films accounting for a large chunk of that growth.