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Themed collection Coronavirus articles - free to access collection

156 items - Showing page 1 of 3
Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

The One-China policy constitutes the political foundation of China-US relations which has remained unshaken despite the changing circumstances, nor can this relationship be undermined. With that foundation in place, we believe that there are broad prospects for China-US cooperation.
在今年的榜单上,美国学校恢复了自己的优势,上榜的美国学校数量增至51所。2016年,这一数据首次跌破50,降至47所。在8所新上榜或重新上榜的学校中,有6所来自美国。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

喜剧类最佳女配角:凯特?麦金侬(Kate McKinnon),《周六夜现场》(Saturday Night Live)
[?'fekn]

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

From the themed collection: 中国制造首先要防“马桶盖陷阱”
Open Access Perspective

Soft matter science and the COVID-19 pandemic

对投资者而言,今年对行业的准确判断还只是个小问题,因为除了美股,今年全球的投资好选择不多。

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

其实,它体现在所有品牌上,它们把六七十年代的服装搬到当季店铺里,包括阿尔伯特·菲尔蒂(Alberta Ferretti)、璞琪(Pucci)和艾绰(Etro)。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
From the themed collection: 家具:进口价格不敌代购
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

政府已经意识到了房地产泡沫的危险性——可能造成国民经济的通货膨胀,甚至可能因为泡沫破灭,最终导致正在复苏的经济脱离正轨。政府已经出台了相关的政策措施,给火爆的房地产市场降降温。在2010年依靠政府出台的政策来调控房价,你认为这有多靠谱?
与去年相比,亚马逊(Amazon)、星巴克(Starbucks)和Facebook今年的品牌价值飙升。亚马逊的品牌价值增长59%,至990亿美元,排名第七,Elspeth Cheung表示,这在一定程度上源于其创造需求、而不仅仅是满足需求的能力。她表示,亚马逊的一小时送货服务对其他零售商加快送货速度构成压力,同时这家在线零售商进入物流领域对联合包裹(UPS)、联邦快递(FedEx)以及DHL等快递公司构成威胁。
Over 90 percent of them attended schools in English-speaking countries, such as the US, the UK and Australia, and over 70 percent pursue at least a bachelor's degree, according to the MOE.
10. 迪皮卡-帕度柯妮 1000万美元

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

不要马上接受工作录用
仿佛是2016年对中国员工还不够艰难,一项年度调查披露,中国逾半数白领雇员在即将到来的(开销巨大的)农历春节假期来临前没有领到年终奖。
这张专辑中十分突出的一首歌《Him》(《他》)以低调的方式讲述了一个有关同性恋和文化偏执的催人泪下的故事,是一首倡导非异性恋者公民权的歌曲。
最佳男歌手:杰森·阿尔丁

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

科学家们让夫妻进入实验室,在他们开始“别扭”对话时观察他们的压力水平。研究发现,面对压力时,用大笑等积极情绪缓解压力的夫妻在一起的时间往往更久。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

加剧人们焦虑的是,新兴市场的企业债务近年不断积累,从2008年至2014年增加了一倍,近年一直是全球债券市场增长最快的领域之一。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

Anne-Sylvaine Chassany
9. Investors brains are so distracted, in denial, they won't get out in time.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

体操、蹦床、竞技体操、艺术体操、
The World Health Organization this year declared H1N1 a global epidemic. Fortunately, it is much less threatening than people previously believed, and newly introduced vaccines seem to have quelled lingering fears.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
From the themed collection: 新三板再扩容 达特照明挂牌上市
Open Access Review Article

Diagnostic technologies for COVID-19: a review

[ri'f?:m]
《每日经济新闻》引用一位专家的话称,银行业已经经历了一个低利润增长期,并且将持续很长一段时间。该专家表示,在过去的十几年里,银行业每年净利润增长达到35%至40%。但现在每年都不到1%,甚至有的银行都进入亏损状态。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

Employment is crucial to ensuring people’s well-being. We will focus our efforts on facilitating employment to see that through their hard work, people can create wealth and realize their full potential.
The new data released yesterday represent the first snapshot of global trade for 2015. But the figures also come amid growing concerns that 2016 is already shaping up to be more fraught with dangers for the global economy than previously expected.
The drama in Nafta
达洛伊西奥常喜欢说“时间是新的货币”。这是一个17岁男孩对人生的睿智洞察,也是Summly软件背后的发展理念。而我们多数人在他那个年龄,时间多得都不知道该怎么做才不会荒废。我很容易就忘了这样一个事实:达洛伊西奥在1995年出生于一个中上层阶级家庭,连高中都还没毕业,还住在小时候住的那个舒服卧室里。在我和他父母聊天的时候,他离开房间去在电脑上干活。只见他穿着袜子下楼,牛仔裤腿扫过大厅的地毯──此时此刻是他最像个孩子的时候。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

其次,尽管人们还守着老的观念,现实却已经发生了变化:供应链管理——也就是确保货物以尽可能低的价格和尽可能高的效率到达目的地——已经成为一项高科技、高风险的行业了。它要求从业者“硬件能力”和“软件能力”缺一不可,而能达到这种要求的人才实在很少。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

该研究的公布正值美国政界反中国言论日益增加之际,此外,今年夏天3起针对从中国进口的钢铁产品的政治敏感反倾销案件即将作出裁决,可能导致美方对中国企业施加高达500%的惩罚性关税。
国考报名将于本月24日截止,而考试将于11月27日在中国各大城市举行。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
From the themed collection: 房企转型瞄准存量市场
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

adj. 社会的,社交的

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
From the themed collection: 水泥业迎史上最严减排标准
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

……一边说从来不会让人看到他流汗,一边汗流不止。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

And now for the companies that lost the most love ...
adj. 被识别的;经鉴定的;被认同者 v. 鉴定(id
安联(Allianz)每4年会举办一次公司内部的国际奥林匹克运动会。所有运动员费用统一由公司负担,届时还有开幕式。2010年的“奥运会”在布达佩斯举办,有超过70个国家的运动员参与。
v. 施压

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

channel
这个领域的创新速度非常快。自从Fitbit于2008年成立以来,各家公司已经发布了五到六个完全不同的产品。三星(Samsung)则在九个月内发布了可穿戴设备Galaxy Gear的三到四个衍生产品。索尼(Sony)、Pebble、谷歌和Facebook的头戴式虚拟现实设备Oculus Rift也紧随其后。
The value created by the service sector rose to 51.6 percent of GDP.
Staff numbers at insurance agencies also rose by 936,200 to a total of more than 5.6m people.
Mark Rutte, the Dutch prime minister whose People’s Party for Freedom and Democracy (VVD) is slightly ahead of the PVV, has seen his poll numbers rise in recent days because of his hardline stance with Ankara. On Tuesday he called Mr Erdogan’s comments “a disgusting distortion of history”, adding: “We will not lower ourselves to this level. It is totally unacceptable.”

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

SIZE: 5,003 square feet total
郑中基和蔡卓妍:手原来是离婚

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

摩洛克位于非洲北部地区,被称为通往非洲的一扇大门,主要旅游城市包括首都拉巴特、最大城市卡萨布兰卡、马拉喀什以及阿加迪尔市。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

直到最近,Weill Cornell Medical College的科学家们至少在老鼠和猴子身上实现了这一点。这种人造视网膜,它的芯片可以将画面转换为电子信号,而它的微型投影机可以将电子信号转化为投影光线。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

裘德韦伯(Jude Webber)
9. 投资者如此不在乎,如此不接受事实,他们不会及时逃出。
1. Battle of the Sexes
波尔图还有一系列较平民的博物馆、廉价的老式有轨电车和迷人的卵石海滩。葡萄园一日游这类短途旅行也非常便于安排。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

Hua Xu Yin is about a princess who sacrificed her life for the country but later was saved and began her own adventures with another name. It is also a TV series adaptation of an online novel of the same title written by Tang Qi. The series premiered in July 2015, staring Lin Yuan and Zheng Jiaying. However, it did not get as much attention as its rivals. According to the online critics, the lead roles and their costumes were not appealing enough in the adaptation.
The US box office, which includes totals from Canada, hit $11.1 billion, an 8 percent increase year-over-year, and was credited to several smash hits, including Jurassic World ($652 million domestically), Avengers: Age of Ultron ($459 million) and Inside Out ($356 million).
我是否在维持健康的人际关系?在你的生活中,是否有一段关系需要你额外的关注?你是否需要给某人平反?在如何对待他人这个问题上,努力保持清醒的头脑。
adj. 自发的,自然产生的

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

由于孙轶潇没带手机,他开始尝试大声呼救以引起外面人的注意,但是时间一分一秒地流过,并没有人回应他。
在最近一连串的几场比赛之前,史蒂芬·库里真的没有想到能够创造这么多的NBA历史纪录。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

张天羽的作品“非常丰富和完整”,谷歌涂鸦团队领导瑞安·格米克对《华盛顿邮报》表示,“仿佛每片树叶都有生命”。
每个伟大的侦探都需要专属于自己的经典故事。对于福尔摩斯而言,这个故事是《巴斯克维尔的猎犬》。对于阿加莎?克里斯蒂笔下龟毛的比利时侦探赫克尔?波洛而言,这个故事是《东方快车谋杀案》——故事讲述了一个嗜血的恶棍在驶向巴尔干半岛的列车上杀死了一个有钱的商人。真相果真是如此吗?西德尼?吕美特曾在1974年将该故事拍成了一部备受喜爱的电影,强大的演员阵容包括肖恩?康纳利、英格丽?褒曼和阿尔伯特?芬尼(饰演侦探波洛)。如今肯尼思?布拉纳自己戴上了侦探波洛的大胡子,披挂上阵,同时又担当幕后导演。这部新版电影的演员有约翰尼?德普、黛西?雷德利、米歇尔?菲佛、佩内洛佩?克鲁斯和朱迪?丹奇。这个故事还能挖掘出什么新内容呢?也许会有。不过,即使没有,阿婆的粉丝也肯定会去看。这部电影将于11月3日在英国上映,11月10日在美国、中国和土耳其上映,11月30日在中国香港和新加坡上映。(资料来源:二十世纪福克斯电影公司)
exposed
6.杰克·谢帕德差点在第一集中死去
She pointed to equal pay, saying it's not "just a woman's issue" but something that affects everyone. "If you have a wife, a mother, a sister, a daughter who is working and they are not being treated fairly, the whole family suffers," Clinton said.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

For once, the Lakers are in good spot and don't have to rush into anything. Take some time. See what they have. They're not making the playoffs with that defense, but that's not really the point of this season anyway.
中国的旅游业官员正力图在2014年扭转入境游客减少的情况,专家认为,如果能对其过时的旅行团进行改进并降低票价,这一计划就有可能实现。
It set minimum prices too high for commodities including cotton, sugar and corn, and as those prices diverged from the market prices, authorities encouraged excessive production as well as strong import flows.

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
From the themed collection: 瓷砖胶是建材行业最后一片蓝海?
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

The ‘one country, two systems’ principle needs to be steadfastly applied in Hong Kong without being bent or distorted.
The report found that third-tier cities are most livable places.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

[si'vi?]
不过,不管怎么说,2018年对中国许多大型国内电影公司来说都是一个强劲的年份。
The University of Pittsburgh team used stem cells made from skin to make MCPs, a special kind of cell that acts as a precursor to cardiovascular tissue. They then placed these cells on a 3-D scaffold designed to support a mouse heart. Within 20 days, the new heart began beating at 40 to 50 beats per minute.

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

译者:清远
These are the major winners of the 68th annual Primetime Emmy Awards. Additional winners are listed at emmys.com.
n. 宪章,特许,(船、机、车等的)租赁

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

[p?izd]

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

I'm pleased to see manufacturing jobs returning to the U.S., but I don't expect the manufacturing industry to have the galvanic effect on the economy that many hope for. Why? Because automation will sharply erode the number of jobs any factory requires. The disappearance of blue-collar and entry-level jobs is already a problem, and that problem will grow.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

此外,他还刷新了他职业新高的助攻数、2分球命中率(63%),还有同样为职业生涯最高的78.5%的罚球命中率。而且,他这赛季的篮板数比职业生涯平均篮板数也多了0.4个。总而言之,詹姆斯本赛季在除得分以外,各项数据都是堪称亮眼。
尽管此次维密秀备受期待,但似乎该内衣品牌在中国的首秀并没有完全按计划进行。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

"Hiring a veteran can be one of the best decisions any of us can make, and Wal-Mart is proud that we have hired more than 26,000 since we announced our Welcome Home Commitment on Memorial Day," Simon told Fortune. "Veterans have a strong record of performance under pressure and passion for service, which makes our pledge to hire, learn from, and support them easy."
《Chandelier》的视频点击量已突破7.12亿,是YouTube点击量最高的MV排行榜上的第17名。
单词toxic 联想记忆:
“Tangerine” (Sean Baker)

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

"Investing in innovation is critical to raising long-term economic growth," said WIPO Director General Francis Gurry. "In this current economic climate, uncovering new sources of growth and leveraging the opportunities raised by global innovation are priorities for all stakeholders."
Princess Agents

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

去年我国内地人口总数达13.7亿,与2010年进行人口普查时相比,人口数量增加了3377万,这意味着人口年增长率为0.5%。
输家:尼克斯

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

五大发展理念:创新、协调、绿色、开放、共享的发展理念

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

沙特王储穆罕默德·本·萨勒曼表示,多数被捕人员已同意归还部分非法获得的钱财,以换取自由。
Interest in wearable technology isn’t limited to technology companies. Mercedes-Benz is porting its mobile experience to a wearable device, while Virgin Atlantic is exploring the customer service aspect of Google Glass on a trial basis. Kenneth Cole is also using Glass as part of a marketing campaign.
The piece was taken away for laboratory testing, and the Spielman family only received a phone call this month telling them the amulet had been identified.
失业率的大幅下降的实际效果将会有所体现

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

单词extend 联想记忆:
200911/88512.shtmlA 1936 Nobel Peace Prize discovered at a South American pawn shop has been sold at auction in Baltimore for $1.16 million.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

There's plenty more to figure out in the coming months, plenty more to speculate about, plenty more to enjoy. Here's wishing all of our readers a safe and enjoyable holiday season, and a happy new basketball year.
Here are our top 10expectations for China in 2014:
新总督还寻求私有化如能源生产部门的服务,设立一个办公室监督和分类联邦资金以减少腐败,并为医生创造财政奖励,以提升日益减少的专家人数。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

《中国日报》(China Daily)援引中国旅游研究院(China Tourism Academy)和北京市旅游发展委员会(Beijing Commission of Tourism Development)的一篇报告称,污染状况加剧以及人民币升值,使得北京去年1月至11月间的外国游客数量从2012年同期的501万人下降至420万人。此前一份基于对国内旅行社的调查的报告显示,去年前三个季度赴北京旅游的游客数量较上年同期下降约50%。
The Caixin-sponsored composite PMI for November came in at 50.5, the first time it had broken through the 50-mark separating contraction from expansion since July.
公司:垃圾处理公司Nation Waste

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

蕾哈娜在榜单上排名第二,获得亚军,《男人装》表示:在这12个月以来,她真是无处不在,但是我们依然没有对她审美疲劳。
2011年,她的妈妈梅丽莎(Melissa)报名参加Lifetime频道的真人秀节目《Dance Moms》。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
From the themed collection: 广州住房公积金租售中心上线
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

2=neutral
凯瑟琳·毕格罗和编剧马克.波尔已经为了这部电影筹备了一段时间,影片讲述的是1967年发生在底特律的警方突袭行动,这次行动引发了美国历史上规模最大的一场民众暴动。出演该片的有凯特林.德弗、约翰.卡拉辛斯基、威尔.保尔特、约翰.波耶加以及杰克.莱诺。
Consumer and producer prices are still either muted or in deflationary territory in China – but last month marked something of an uptick for each.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

Yet the TV adaption couldn’t satisfy the audience, who prefer real history rather than fiction, and it only got 4.9 points on Douban.
Net interest margins — the difference between interest paid on deposits and interest gained from loans — suffered as China lifted its remaining controls on the interest rates paid on deposits. The average margin declined by about 46 basis points to 2.54 per cent in 2015.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

在这欢乐的时节给你我最真的祝福和亲切的思念,愿你今年的新年比往年更璀璨。
8Australia
位于华盛顿特区的乔治敦大学(Georgetown University)麦克多诺商学院(McDonough business school)重新回到了定制课程排行榜的第15位,去年,该校因客户调查反馈率低而未上榜。只有3所学校是首次登上定制课程排行榜,包括排名第60位的伦敦卡斯商学院(Cass Business School)。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Forex reserves fell $87bn in November, near the record $94bn decline suffered in August — the same month that the central bank surprised global markets by allowing the renminbi to depreciate by 3 per cent in three days.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
From the themed collection: 北京1月1日至5日暂停网签
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

在所有这些影片中,斯文顿用的是同一个牙齿设计专家——伦敦Fangs F/X公司的克里斯·莱昂斯(Chris Lyons)。他在工作中设计了各种牙齿,包括为坎耶·韦斯特(Kanye West)一个音乐录影带中的一只杜宾犬设计了金色尖牙。
她还表示,由于西方一些国家的经济条件和反移民情绪,许多中国学生发现现在很难留在这些国家。

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

"我认为机器会比人类更强大、更智能,但绝不会比人类更睿智。"马云如是说。“因为有一件事是肯定的:智慧、灵魂和心灵都是人类所拥有的东西,而机器永远不能享受失败、成功、友谊或爱情。”
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Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
From the themed collection: 北京至雄安将建京安高速
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

这一次,湖人队处境不错,而且不需要赶着去做什么事,给他们点时间,看看他们到底会怎样。用这样的防守质量他们很难进入季后赛,但是这并不是这个赛季的重点。
这些利好消息为特斯拉带来了极为惊人的估值。一位名叫佐尔坦o班的特斯拉观察人士在金融网站“寻找阿尔法“(Seeking Alpha)上指出,特斯拉现在的估值,相当于它每年已经能够卖出几十万辆汽车,但实际上今年它只能卖出35,000多辆车。从另一个角度来说,特斯拉公司今年卖出的每一台车,估值相当于高达100万美元。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

今年1月3日春节假期车票开售以来,约有2.8亿张火车票是在12306网站上售出的。
After enjoying a weekend of football in Manchester, David Beckham quickly jetted across the Pond to New York last night to spend Valentine’s Day with his p

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

Once Upon A Time

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

Wishing you all the happiness of the holiday season.祝节日幸福如意。
10. A bad marriage can lead to an early death
小编碎碎念:华裔球员林书豪的一夜爆红,让因病缺阵的尼克斯当家球星小甜瓜安东尼颇有几分“躺着也中枪”的无辜感。
朴雅卡 乔普拉

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

Although the banks' dividend to shareholders is shrinking, it still accounted for half of the combined dividends of all public companies in China. The banks' earnings also made up 52% of the total profits reported by listed companies last year.

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

科比也不幸成为本赛季当中第1位至少投篮14次却只拿下4分甚至更少的球员。
At the center of the speculation is BlackBerry’s healthy intellectual property portfolio, 44,000 patents and still growing. Last October, for example, the company won at least 27 new ones—covering everything from conference-calling interfaces to touch screens to security features for wearable technologies such as smart watches, eyeglasses and fitness bands. Security continues to be BlackBerry’s biggest selling point with businesses. Just ask the Sony movie studio division, which “resorted” to outdated BlackBerrys to restart communications after its security breach last Thanksgiving.
One key thing the best bosses seem to have in common is that they are all consummate problem solvers. They can not only spot them, but brainstorm successful and innovative ways to fix them。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

我只是忍不住希望,随着《广告狂人》的终结,一个时尚阶段也能终结,在这个阶段,设计师们被困于过去的时代,几乎窒息——至少是困在20世纪60年代(不要忘了,60年代初与50年代末非常相似)至70年代初。
It’s sometimes one of the scariest words in the English language, but it’s a word you should be prepared to say when opportunities arise in your career: Yes.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

but that was markedly lower than the previous month’s rise of 8.2 per cent.
The circular also stressed zero tolerance for cheating.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

5.E-Cigarettes

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
From the themed collection: 湖南整治不动产登记窗口作风问题
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

Xi'an Xianyang International Airport outshone all other airports in China, with a punctuality rate of 82.3%.
Apple Chief Executive Officer Steve Jobs holds the new " iPad" during the launch of Apple's new tablet computing device in San Francisco, California, in this January 27, 2010
教育行业基本上还未受到在线服务交付的影响——但可能会在2018年经历戏剧性的变化。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

自1983年以来,每年的央视春晚就成为了中国人民春节必不可少的重要组成部分,也难怪主办方的每个举动都能成为关注的焦点。
2014年至2016年期间,虽然全球增长数据不错,但全球温室气体排放量持平,所有人都为此欢欣鼓舞。问题是,其原因并非是所有人庆祝的全球经济效率提升,而仅仅是中国北方的经济增长放缓。随着这部分地区在2017年恢复了经济增长势头,二氧化碳排放量开始再次上升。
The media are annoying, we get that, Your Royal Highness, but there may have been more dignified ways for you (and the establishment you represent) to air your concerns.
2.全球谋杀案

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

回忆:fanfare(n 夸耀)
此外,华为在2016年最后一季度第一次实现了2位数的全球市场占有率。

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
From the themed collection: 北京多部门启动调查”租房贷“
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

日本央行行长黑田东彦(Haruhiko Kuroda)表示:“我觉得我们可以对全球前景持谨慎乐观态度。”
Dawn Hudson, Academy CEO:
会。美国政府在垂直合并案上已有数十年没赢过。据美国司法部(Department of Justice)自己的审查指导原则,像时代华纳这样的内容所有者与AT&T这样的分销商之间的“垂直合并”,远不如水平合并那么令人担忧。与此同时,Facebook、亚马逊(Amazon)、Netflix和谷歌(Google)这四巨头(合称FANG,取每家名称首字母)如今主宰了数字娱乐版图,这使得政府的如下论点更难以站住脚:两家传统媒体公司的合并,会从根本上改变竞争态势。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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“温总理的讲话重点提到了经济和社会发展。中国政府为实现建设繁荣社会这一目标付出了巨大的努力。”Irene Giner-Reichl, Austrian ambassador
Meanwhile, exports are expected to continue falling due to the combination of weak global demand and higher prices, as well as China’s decision to effectively re-peg the renminbi to the strengthening dollar.

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